Rol de la función mitocondrial en el corazón y sus implicaciones en disfunciones cardíacas
Por:
Franco, Nicolas David
Publicada:
1 nov 2017
Resumen:
Abstract In this review article, we examined the role of mitochondria in
the good functioning of the heart, and in the generation of various
cardiac conditions, which are characterized by low energy production by
the mitochondria and therefore, there is an increase in the loss of
cardiomyocytes that leads to malfunction of the heart. It has been
determined that certain mitochondrial dysfunctions associated with
cardiac disorders are related to alterations of the oxidative
phosphorylation system, as well as to the reduction of certain
structural components such as cardiolipin and the formation of
supercomplexes. It is estimated that about 2.3% of the Colombian
population may present prevalence to heart failure. The objective of the
present review is to present the investigative advances related to
cardiac diseases caused by mitochondrial dysfunction, as well the
identification of different investigations directed at the creation of
treatment alternatives for these pathologies, all in order to contribute
to the construction of lines of work that take the mitochondria as a
therapeutic target.
Filiaciones:
Franco, Nicolas David:
Universidad Eafit
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